The vertical transmission is COVID-19 is extremely rare, and meta-analysis has shown.

The transmission of COVID-19 through the vertical axis is possible but not typical and more petite than the percentage of children born to mothers suffering from COVID-19 who test negative for the disease in a study released in the BMJ.

“The principal issue with SARS-CoV-2 and the pandemic is any time a mother gets SARS, the first concern they have is ‘what will occur to my baby what happens to my baby?” Shakila Thangaratinam, Ph.D. Professor of perinatal and maternal health and co-director of WHO Collaborating Centre for Global Women’s Health at the University of Birmingham, the United Kingdom, she said to Healio. “This is the same issue health professionals are thinking over … To answer this question, we need to know the percentage of moms who suffer from the illness and their children are also positive.

“The second question is: can the virus spread from the mother to the baby is still in the womb, while it is still being delivered, or even after?” said Thangaratinam, who is also the head of the reproductive and maternal health research area within the University of Birmingham. “The second concern concerns what will happen to babies who have been infected.”

Data collection

Thangaratinam and her colleagues examined 472 studies accessible on databases between December. 1st, 2019, until the 3rd of August. 3rd, 2021, which included 28.952 mothers and 18,237 children.

The study included 206 cohort studies of pregnancies or recently-pregnant women admitted to the hospital, who were positive for COVID-19, and provided information about the child’s status concerning SARS-CoV-2 within 30 days of birth. There were 266 studies and case reports used to determine if transmission occurred during the uterus, intrapartum, or the first postnatal days and the probability of information.

SARS-CoV-2 positive, and results

Of 14,271 infants born to mothers with COVID-19, 1.8% (95% C.I, 1.2%-2.5%; 140 studies) confirmed the presence of COVID-19 by using reverse transcriptase polymerase chain reaction (RT-PCR) tests.

Information on the timing of exposure and the type and timing of test results were discovered for 592 infants born to mothers who were COVID-19 positive, 14 of whom had confirmed transmission from mother to the child according to WHO classification. This included four live births that had in utero news. There were also three miscarriages or deaths of fetuses transmitted in utero, two intrapartum messages, and five prenatal exposures.

Results were available for 880 babies who were positive for the SARS CoV-2. For those who were not alive at the follow-up period, there were twenty stillbirths, 23 neonatal deaths, and eight early pregnancy deaths.

The characteristics of mothers associated with the babies who tested positive for SARS-CoV-2 were extreme COVID-19 (OR = 2.36 95 percent CI 1.28-4.36 22 studies) and death (OR = 14.09 9.5 percent CI, 4.14-47.97 Seven studies) the admission into the ICU (OR is 3.46 (95 percent CI, 1.74-6.91 19 analysis) and postnatal infections (OR of 4.99 (95% confidence interval = 1.24-20.13 Twelve studies).

“The consequences of this are that if mom is suffering from severe COVID-19, it is likely that the child will be positive, and I believe as clinicians, we should keep a check on babies who are born to mothers suffering from severe COVID-19 who require an admission into a hospital” Thangaratinam stated.

The doctor also suggested that confident breastfeeding and mother-baby separation practices shouldn’t be altered due to COVID-19 transmission concerns.

As the years progressed, Thangaratinam recommended that future studies focus on determining the percentage of babies affected by SARS-CoV-2 during the uterus and generating greater and better quality information.

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